发明名称 |
(2'-5')-Oligo (3'-deoxyandenylate) and derivatives thereof |
摘要 |
3'-deoxyadenosine 5'-triphosphate is oligomerized to form (2'-5')-oligo (3'-deoxyadenylate) by incubation with adenosine triphosphate: (2'-5')-oligo adenosine adenyl transferase, in the presence of an inert support carrying a double stranded polynucleotide. The (2'-5')-oligo (3'-deoxyadenylate) is digested with a suitable phosphatase to remove the terminal phosphate groups. The thus produced corresponding 3'-deoxyadenosine compound is an anti-viral material effective against Herpes simplex infection and effective in inhibiting the transformation of cells infected with Epstein Barr virus.
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申请公布号 |
US4539313(A) |
申请公布日期 |
1985.09.03 |
申请号 |
US19840605004 |
申请日期 |
1984.04.27 |
申请人 |
RESEARCH CORPORATION |
发明人 |
SUHADOLNIK, ROBERT J.;WU, JOSEPH M.;DOETSCH, PAUL;HENDERSON, EARL E. |
分类号 |
C07H19/06;C07H19/16;C07H21/00;C12P19/34;(IPC1-7):A61K31/70 |
主分类号 |
C07H19/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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