| 摘要 |
NEW MATERIAL:3-[2-[4-( 2-Methoxyphenyl )-1-piperazinyl]ethyl]-1,3-(3H)benzoxazine-2,4-dione expressed by formula I and a salt thereof. USE:A remedy for diseases in circulatory organs, particularly diseases in cerebral circulatory organs. PREPARATION:Acetylsalicyloyl chloride expressed by formula IV is reacted with 1-(2-methoxyphenyl)-4-(2-aminoethyl)piperazine expressed by formula V in a solvent in the presence of a base to form a compound expressed by formula III, which is reacted with an aqueous solution of NaOH in methanol solvent to give a compound expressed by formula II. The resultant compound expressed by formula II is then reacted with ethyl chlorocarbonate in an inert solvent in the presence of a base, e.g. triethylamine, to afford the aimed compound expressed by formula I .
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