| 摘要 |
PURPOSE:To improve the production efficiency in the production of L-lysine by fermentation, by using obly the microorganisms essentially of the secretion phase. CONSTITUTION:An L-lysine-producing microbial strain [e.g. Corynebacterium glutamicum (ATCC-21513)] is cultured in a medium added with sugars (e.g. glucose, blackstrap molasses, etc.) and a nitrogen source (e.g. ammonium sulfate, urea, etc.) at about 6-9pH and about 15-37 deg.C under aeration. After the completion of fermentation, the microorganisms are separated from the medium, and the produced L-lysine is collected. In the above process, only the microorganisms essentially of the secretion phase (i.e. the cells proliferated separately and finished its proliferation phase, or the cells separated from the conventional L- lysine fermentation system after the completion of fermentation) is used as the microbial strain.
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