发明名称 |
Diffusion coated multiple-units dosage form. |
摘要 |
<p>In an oral pharmaceutical controlled releasable multiple-units formulation, individual units containing an active substance are coated with a substantially water-insoluble, but water-diffusible controlled release coating which includes 1) an inner film layer comprising a homogenous combination of a water-dispersible film-forming agent and a polymeric substance which imparts compressibility to the coating, and 2) optionally an outer film layer comprising a film-forming agent which prevents adhesion between the units at elevated temperatures and imparts flowability to the units.
<??>The coating possesses a sufficient plastic deformability to result in no significant changes in the release characteristics of compressed coated units relative to non-compressed coated units. </p> |
申请公布号 |
EP0153104(A2) |
申请公布日期 |
1985.08.28 |
申请号 |
EP19850300844 |
申请日期 |
1985.02.08 |
申请人 |
A/S ALFRED BENZON |
发明人 |
KJORNAES, KIM;LINNEMANN, JORGEN |
分类号 |
A61K9/20;A61K9/00;A61K;A61K9/14;A61K9/22;A61K9/48;A61K9/50;A61K9/52 |
主分类号 |
A61K9/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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