发明名称 |
Diffusion coated multiple-units dosage form. |
摘要 |
<p>In an oral pharmaceutical controlled releasable multiple-units formulation, individual units containing an active substance are coated with a substantially water-insoluble, but water-diffusible controlled release coating which includes
1) an inner film layer which causes adhesion between the units at elevated temperatures, comprising a water-dispersible film-forming agent, and
2) an outer film layer comprising a water-based film-forming agent which prevents adhesion between the units at elevated temperatures and imparts flowability to the units.
<??>The inner film layer may additionally comprise a substance which is capable of forming a continuous phase.
<??>By subjecting the thus coated units to heating to accelerate the formation of a continuous phase of the film-forming agent of the inner layer and optionally also of the additional substance, a coating is formed which substantially does not change its diffusion characteristics in the course of time. </p> |
申请公布号 |
EP0153105(A2) |
申请公布日期 |
1985.08.28 |
申请号 |
EP19850300845 |
申请日期 |
1985.02.08 |
申请人 |
A/S ALFRED BENZON |
发明人 |
KJORNAES, KIM;CHRISTENSEN, FINN NORRING;JENSEN, JENS RASMUS |
分类号 |
A61K9/00;A61K;A61K9/14;A61K9/20;A61K9/22;A61K9/48;A61K9/50;A61K9/52 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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