1-Oxo-1,2,3,4-tetrahydro-3-isoquinoline carboxylic acid derivatives

摘要

The following new isocarbostyryl derivatives represented by the general formula [I]: <IMAGE> [I] wherein R1 is a hydrogen atom or a lower alkyl group, are provided, said derivatives having excellent angiotensin converting enzyme inhibitory activity with expectations therefore being as a hypotensor, and prepared by solvolysis of a compound of the following general formula [II]: <IMAGE> [II] wherein R1 is the same as defined above, R2 is an acyl group, and R3 is a hydrogen atom, an alkyl group or an aralkyl group.