发明名称 |
Lyophilized cyclophosphamide |
摘要 |
A lyophilized pharmaceutical solid composition containing cyclophosphamide for reconstitution with water to provide a solution for oral or parenteral administration. This lyophilized cyclophosphamide solid composition demonstrates improved stability, solubility characteristics and enhanced appearance compared with currently available dry powder pre-mix compositions of cyclophosphamide. The lyophilized solid composition contains about 20 parts by weight of cyclophosphamide, about 11/4-2 parts by weight of water and from about 10-85 parts by weight of excipient which is comprised mainly of mannitol. Processes for making the composition are disclosed.
|
申请公布号 |
US4537883(A) |
申请公布日期 |
1985.08.27 |
申请号 |
US19840589202 |
申请日期 |
1984.03.13 |
申请人 |
MEAD JOHNSON & COMPANY |
发明人 |
ALEXANDER, ROBERT L.;BEQUETTE, ROBERT J.;KENSLER, TERRY T.;SCOTT, JOSEPH A. |
分类号 |
A61K9/00;A61K9/19;A61K31/675;A61K47/26;(IPC1-7):A61K31/66 |
主分类号 |
A61K9/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|