NICOTINIC DERIVATIVES OF GLUCOSAMINE, PROCESS FOR THEIR PREPARATION AND RELATED PHARMACEUTICAL COMPOSITIONS

摘要

Nicotinic derivatives of glucosamine, particularly N-nicotinoyl-glucosamine tetranicotinate have useful antilipolitic, hypocholesterolemizing and anti-aterogenic activities, at a like or higher level than those of nicotinic acid, without the objectionable side effects as shown by the acid. For the preparation of the compounds of the invention nicotinoyl chloride hydrochloride and glucosamine hydrochloride are reacted in an organic solvent at a temperature of between 40.degree.C and 120.degree.C.