| 摘要 |
The title compounds I (R1 = H, lower alkyl, phenyl; R2=R3=H, hydroxy, C1-6 alkoxy, C1-6 aliphatic group) and their derivatives, used in the extermination of insects especially distoma, were prepared using a novel method. Thus, 1-phenyl-6-acetyl-8,8-dimethoxy3,6-diazooctane-4- on was cyclized under an acid catalyst to give 92% 1-(2-phenyl)ethyl- 4-acetyl-6-hydroxy piperazine-2-on without using a difficult process. Acids used in the reaction were selected from H2SO4, HCl, methan sulfonic acid, formic acid and p-toluene sulfonic acid, etc.
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