| 摘要 |
<p>Compound of formula (I) and pharmaceutically acceptable salts thereof:
<CHEM>
wherein:
R1 is hydrogen, C1-6 alkyl or phenyl optionally substituted by halogen, CF3, C1-4 alkoxy or C1-4 alkyl;
R2 is hydrogen or C1-6 alkyl;
R3 is hydroxy, nitro, cyano, C2-10 acyloxy, NR6R7 wherein R6 and R7 are independently selected from hydrogen, C1-6 alkyl, C2-7 alkanoyl or C1-6 alkylsulphonyl; or COR8 wherein R8 is hydroxy, C1-6 alkoxy or NR9R10 wherein R9 and R10 are independently selected from hydrogen or C1-6 alkyl;
R4 is hydrogen, halogen, CF3, C1-4 alkoxy, C1-4 alkyl or any of the groups listed for R3; and
R5 is hydrogen, C1-4 alkyl or benzyl optionally substituted in the phenyl ring by halogen, CF3, C1-4 alkoxy or C1-4 alkyl and is attached at nitrogen atom 1 or 2, having anti-inflammatory and/or anti-allergy activity, a process for their preparation and their use as pharmaceuticals. </p> |
