| 摘要 |
PURPOSE:To obtain the titled (substituted) compound useful as a raw material for medicines and agricultural chemicals in high yield, by catalytically reducing a (substituted) nitrophenyl ketone in the presence of a Raney-nickel catalyst and a cyano compound efficiently under pressure of hydrogen. CONSTITUTION:A nitrophenyl ketone which may be substituted, e.g. m-nitroacetophenone, is catalytically reduced preferably in a solvent, e.g. methanol, in the presence of a Raney-nickel catalyst and a cyano compound at 50-150 deg.C, industrially and advantageously 70-120 deg.C under 2-100kg/cm<2>, preferably 5- 50kg/cm<2> H2 pressure to afford the aimed aminophenyl ketone which may be substituted, e.g. m-aminoacetophenone. An inorganic or organic cyano compound is used as the cyano compound, and for example dicyandiamide, calcium cyanamide, dicyanoethane, diaminomaleonitrile, 4-cyanopyridine, etc. are used. |
