摘要 |
PURPOSE:To obtain the titled compound of high optical purity in high yield, by resolving a complex of DL-phenylalanine with an optically active mandelic acid optically in a solvent containing an aldehyde compound to remove the mandelic acid. CONSTITUTION:A complex of D,L-phenylalanine with optically active mandelic acid is resolved optically in a solvent containing an aldehyde, e.g. salicylaldehyde or anisaldehyde, preferably in the presence of an aliphatic carboxylic acid, phosphoric acid and a salt thereof, etc. added thereto to give a complex of the optically active phenylalanine with the optically active mandelic acid, which is then treated with an ion exchange resin or neutralized, etc. to remove the mandelic acid and afford the aimed substance. USE:The L-isomer is useful as one component in amino acid transfusion solutions or a raw material for synthetic sweeteners, and the D-isomer is useful as a raw material for medicines, etc.
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