| 摘要 |
<p>PURPOSE:To obtain the titled compound useful as an inhibitor of blood platelet aggregation, carcinostatic agent, drug for central nervous system, etc., by deoxidation of hydroxyl group at 7 position of 7-hydroxy PGF2 and functional group conversion of hydroxyl group. CONSTITUTION:A compound shown by the formula I (R<11> is 1-10C alkyl, or tri 3-7C hydrocarbon; R<2> and R<3> are H, 1-10C alkyl, or cycloalkyl; R<31> is tri 1- 7C hydrocarbon silyl; R<41> and O of OH form acetal bond; A is double or triple bond) is treated with thiocarbonylimidazole, then with a tri-n-butyltin hydride, and further with a base to give a compound shown by the formula II. OH at 9 position is protected with a group which is linked to O of OH to form an acetal bond, to give a protected prostaglandin F2alpha, which is selectively deprotected, oxidized, and deprotected or hydrolyzed to give a compound shown by the formula III (R<1> is H, or 1-10C alkyl; R<4> and R<5> are H, or a group which is linked to O of OH to form acetal bond).</p> |
