P-HYDROXYPHENYLGLYCINE ALPHA-PHENYLETHANESULFONATE, PROCESS FOR PRODUCTION THEREOF AND UTILIZATION THEREOF IN RESOLUTION OF P-HYDROXYPHENYLGLYCINE

摘要

p-Hydroxyphenylglycine. alpha -phenylethanesulfonate which is useful for the production of optically active p-hydroxyphenylglycine and optically active alpha -phenylethanesulfonic acid is disclosed. p-Hydroxyphenylglycine. alpha -phenylethanesulfonate is produced by either reacting DL-p-hydroxyphenylglycine with optically active alpha -phenylethanesulfonic acid or reacting (+/-)- alpha -phentylethanesulfonic acid with optically active p-hydroxyphenylglycine to form two diastereomers of DL-p-hydroxyphenylglycine optically active alpha -phenylethanesulfonate or optically active p-hydroxyphenylglycine (+/-)- alpha -phenylethanesulfonate, and isolating one diastereomer according to the difference between solubilities of the diastereomers, optionally, combining selective crystallization of one diastereomer and epimerization of another diastereomer in the case of reaction of DL-p-hydroxyphenylglycine and optically active alpha -phenylethanesulfonic acid. This reaction is utilized in the resolution of p-hydroxyphenylglycine or alpha -phenylethanesulfonic acid by deacidifying the resulting diastereomer.