SUBSTITUTED 5-HYDROXY-2,3-DIHYDROBENZOFURAN AND ANALOGUE USEFUL AS ANTIINFLAMMATORY

摘要

Novel substituted 5-hydroxy-2,3-dihydrobenzofurans and analogs thereof having the general formula …… and pharmaceutically acceptable salts thereof are disclosed wherein m is an integer ranging from 1 to 4;… A is… (a) phenyl substituted with (R<1>)q wherein when there are more than one R<1> (q > 1) R<1> can be the same or different from each other and is… (1) hydrogen;… (2) halo;… (3) loweralkoxy;… (4) lower alkylthio;… (5) lower alkyl sulfinyl;… (6) lower alkyl sulfonyl;… (7) unsubstituted or substituted phenyl; loweralkoxy;… (8) loweralkyl… (9) loweralkenyl;… (10) lower alkanoyl;… (11) haloloweralkyl;… (12) -COOH or -COOC1-6alkyl;… (13) aryl;… (14) aryloxy;… (15) cyano;… (16) hydroxyloweralkyl;… (17) halo loweralkanoyl;… (18) heteroaryl as defined below; or… (19) loweralkanoyloxy;… q is an integer ranging from 0 to 5;… (b) unsubstituted or substituted heteroaryl selected from a group consisting of:… (1) thienyl;… (2) benzothienyl;… (3) furyl;… (4) benzofuryl;… (5) pyrryl;… (6) indolyl;… (7) thiazolyl;… (8) benzothiazolyl;… (9) thiadiazolyl;… (10) benzothiadiazolyl;… (11) quinolyl;… (12) isoquinolyl;… (13) pyridyl;… (14) pyrazinyl;… (15) tetrazolyl; or… (16) triazolyl,… the heteroaryl above being substituted with one or more of R<1>. …Those compounds are useful as anti-inflammatory agents. A Process for preparing those compounds is also disclosed.