| 摘要 |
PCT No. PCT/US82/01349 Sec. 371 Date Apr. 3, 1984 Sec. 102(e) Date Apr. 6, 1984 PCT Filed Sep. 29, 1982 PCT Pub. No. WO84/01378 PCT Pub. Date Apr. 12, 1984.UI (Urotensin I) or carp urotensin, obtained from Cyprinus carpio, has the formula: H-Asn-Asp-Asp-Pro-Pro-Ile-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Asn- Met-Ile-Glu-Met-Ala-Arg-Asn-Glu-Asn-Gln-Arg-Glu-Gln-Ala-Gly-Leu-Asn-Ar g-Lys-Tyr-Leu-Asp-Glu-Val-NH2. UI or a biologically active fragment thereof or a pharmaceutically acceptable salt of either, dispersed in a pharmaceutically acceptable liquid or solid carrier, can be administered to mammals to achieve a substantial elevation of ACTH, beta -endorphin, beta -lipotropin and corticosterone levels and/or a lowering of systemic blood pressure over an extended period of time.
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