| 摘要 |
NEW MATERIAL:The PGD-analogue compound of formula I [PG<1> and PG<2> are same or different group of formula II or formula III (X<1> and X<2> are ethylene, etc.; R<1a> and R<1b> are 1-5C alkylene, etc.; R<2a> and R<2b> are 1-8C alkyl, etc.); the double bond between C9 and C10 in the group of formula II and formula IIIrepresents the configuration Z; when R<1a> or R<1b> is single bond, then R<2a> or R<2b> is not substituted or unsubstituted phenoxy), its antipode, or their mixture; Y<1> Y<2> are O, etc.; n is integer of 2-8] or its cyclodextrin clathrate compound. EXAMPLE:The compound of formula IV. USE:Antitumor agent. PREPARATION:The compound of formula I can be produced by reacting the compound of formula V with isobutyl chloroformate in a solvent such as THF, converting the reaction product to the compound of formula VI, and reacting the compound with the compound of formula VII in a manner similar to the above reaction.
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