| 摘要 |
<p>The present invention relates, by way of new industrial products, to 1-(acetylaminophenyl)-2-amino-propanone derivatives selected from the group consisting of (a) the compounds of the formula Ar-CO-CH(CH3)-NR1R2(I) in which R1 represents a C1-C4 alkyl group or a C3-C6 cycloalkyl group; R2 represents the hydrogen atom or a C1-C4 alkyl group; R1 and R2, taken together, can form, with the nitrogen atom to which they are bonded, an N-heterocyclic group with 5 to 7 ring members, capable (i) of including a second heteroatom selected from N, O and S, and (ii) of being substituted, the said heterocyclic group NR1R2 being selected from the group comprising pyrrolidino, morpholino, thiomorpholino, piperidino, hexamethyleneimino, piperazino, 4-methylpiperazino, 4-( beta -hydroxyethyl) piperazino, 4-phenylpiperazino and 4-(p-chlorophenyl)-piperazino groups; and Ar represents an acetylaminophenyl group of the formula <IMAGE> in which X is CH3CONH and Y and Z, which can be identical or different, each represent a hydrogen or halogen atom; and (b) their addition salts. These new products are useful as anti-depressants for the central nervous system. The invention also relates to the method for their preparation.</p> |
