发明名称 |
IMPROVEMENTS RELATING TO GROWTH FACTORS |
摘要 |
<p>Neoplastic and other diseases can be diagnosed by assaying a human test sample e.g. body fluid, tissue or cultured tumour explant cells, for structurally altered or abnormally expressed growth factor receptors or for the nRNA transcripts of genes which encode them. For example, the assay can be for truncated EGF receptor having at least a portion of its mature amino terminus deleted. Antibodies, capable of binding a predetermined amino acid sequence within the EGF receptor, are also useful in diagnosis and therapy as are conjugates of an immunogenic polymer bound to a polypeptide fragment of EGF receptor. DNA and RNA encoding EGF receptor or fragments thereof are also decribed.</p> |
申请公布号 |
WO8503357(A1) |
申请公布日期 |
1985.08.01 |
申请号 |
WO1985GB00045 |
申请日期 |
1985.01.30 |
申请人 |
ICRF PATENTS LTD.;YEDA RESEARCH & DEVELOPMENT CO. LTD.;GENENTECH INC. |
发明人 |
WATERFIELD, MICHAEL, D.;SCHLESSINGER, J.;ULLRICH, AXEL |
分类号 |
A61K38/00;A61K39/395;A61K47/48;A61K49/00;C07K7/04;C07K14/71;C07K16/28;C12N;C12P21/00;C12Q1/68;G01N33/574;G01N33/74;H01L21/027;(IPC1-7):G01N33/574;C07K15/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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