| 摘要 |
<p>Compounds of the formula (I) <CHEM> in which: A is -NR-(CH2)n,-NH2 or -NR-(CH2)n-NH-@@NR2; Z is Phe, Phe(4 min -Alk) or Tyr(Alk); X is D-Phe, D-Phe(4 min Alk), D-Val, D-Nva, D-Leu, D-Ile, D-Pba, D-Nle, D-Cha, D-Abu, D-Met, D-Chg, D-Tyr, L-Tyr, D-Tyr(Alk) or L-Tyr(Alk); P is D-Pro, L-Pro, DELTA <3>-Pro, L-Ala, L-N-MeAla, L-Gly, L-Sar or a single bond; Y is Val, Ile, Abu, Ala, Chg, Gln, Lys, Cha, Nle, Phe, Leu or Gly; R is, in each case, hydrogen or C1-5-alkyl; n is an integer from 2-8; m is an integer from 0-2; and Alk is C1-4-alkyl; and pharmaceutically acceptable acid addition salts thereof are vasopressin antagonists. Their preparation and pharmaceutical use are described.</p> |
