摘要 |
<p>Improved process for conversion:- - where X = F or Cl. - Prepn. of highly active 9alpha-F or 9alpha-Cl anti-inflammatory steroids (esp. pregnanes) - (i) Applied to steroid sol. is not 3 pts./100 pts. reactn. mixt. - (ii) Acid concn. HCl:- 30-38% (w/w) - Hf:- 48-79% (w/w) - (iii) Temp. -30 deg. to + 35 deg. - (iv) Time. 5 min.-24 hr. - (v) Also claims applicn. to 16beta-Me and 16alpha-OH analogues.</p> |