| 摘要 |
<p>Cephloxime, (6R,7R)-3-carbamoyloxymetyl-7-(2-(2-fury)-2methoxy iminoacetamide)-3-cephem-4-carboxylic acid (synisomer) of formula (I) is produced by reacting the reactive deriv. of 2-(2furyl)-2-mthoxy iminoacetic acid of formula (IV) (where R' is opt. substd. alkyl, aryl, aralkyl, cycloalkyl, or heterocyclyl) with (6R,7R)- carbamoyloxymethyl-7-amino-3-cephem-4-carboxylic acid of formula (V) in a polar solvent (e.g. N,N-dimethylacetamide, etc.) at temp. of -40 to +60OC for 0.5-48 hrs. in the presence of an acylating agent. Cephloxime antibiotic having a high activity on large numbers of gram-positive and negative microorganisms can be produced economically.</p> |
