发明名称 |
Pharmaceutical formulation. |
摘要 |
<p>A controlled absorption diltiazem formulation for oral administration comprises a pellet having a core of diltiazem or a pharmaceutically acceptable salt thereof in association with an organic acid and a lubricant, and an outer membrane which permits release of diltiazem in an aqueous medium at a controlled rate which is substantially pH independent. The pellet has a dissolution rate in vitro, which when measured according to the Paddle Method of U.S. Pharmacopoeia XX, is not more than 10% of the total diltiazem after 2 hours of measurement in a buffered medium. Not more than 30% of the total diltiazem is released after a total of 4 hours measurement and not more than 40% of the total diltiazem is released after a total of 6 hours. 100% release is achieved after 12 hours, with a maximum of 80% of the total diltiazem being released after 8 hours.</p> |
申请公布号 |
EP0149920(A2) |
申请公布日期 |
1985.07.31 |
申请号 |
EP19840309032 |
申请日期 |
1984.12.21 |
申请人 |
ELAN CORPORATION P.L.C. |
发明人 |
PANOZ, DONALD EUGENE;GEOGHEGAN, EDWARD JAMES |
分类号 |
C07D281/10;A61K9/00;A61K9/16;A61K9/22;A61K9/48;A61K9/50;A61K9/52;A61K9/62;A61K31/55;A61K31/554;A61P3/00;A61P9/08;A61P9/10;(IPC1-7):A61K31/55 |
主分类号 |
C07D281/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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