FOERFARANDE FOER FRAMSTAELLNING AV NYA CIS-4-FENYL-1,2,3,4-TETRAHYDRO-1-NAFTALENDERIVAT ANVAENDBARA SOM DEPRESSIONSLAEKEMEDEL

摘要

Novel cis-isomeric derivatives of 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine are useful as antidepressant agents. These novel compounds act to block the synaptosomal uptake of serotonin (5-hydroxy-tryptamine), thereby alleviating serotonin abnormalities at central receptor sites. The preferred embodiment is the enantiomer cis-(1S)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthal enamine and its pharmaceutically acceptable acid addition salts.