15-DEOXY-16-HYDROXY PROSTAGLANDIN

摘要

15-DEOXY-16-HYDROXY PROSTAGLANDINS Analogues of PGE1 having the structural formula, < IMG > in which R1 and R2 are hydrogen; R3 is selected from the group consisting of hydrogen or methyl, or together with R4 is a methylene or a lower alkylated methylene chain of 4 to 5 carbon atoms such that a cycloalkyl or a lower alkylated cycloalkyl of 6 to 7 carbon atoms inclusive is formed, or together with R4 is a bicycloalkyl or bicycloalkenyl moiety having the formula: < IMG > such that a bicycloalkyl or bicycloalkenyl compound is formed, wherein p is an integer having a value of from 0 to 1 and q is an integer having a value of from 2 to 3 and wherein the double bond of such bicycloalkenyl is in the q bridge; R4 is hydrogen or methyl or together with R3 forms a cycloalkyl or bicycloalkyl or bicycloalkenyl as defined above or together with R5 is a methylene chain of 3 carbon atoms such that a cycloalkyl of 4 carbon atoms inclusive is formed; R5 is hydrogen or methyl or together with R4 forms a cycloalkyl as defined above; and R6 is hydrogen or a straight-chain alkyl of 3 carbon atoms.