| 摘要 |
PURPOSE:To obtain an excellent filling agent for chromatography by making phosphoric acid or a calcium salt thereof react with a calcium compound in an organic solvent to form a specified hydroxy apatite easily with a better reproducibility. CONSTITUTION:Phosphoric acid or a calcium salt thereof such as calcium hydrogenphosphate 2 water (CaHPO4.2H2O) is made to react with a calcium compound such as calcium hydroxide [Ca(OH)2] in an organic solvent, for example, n-hexane and water at about 60 deg.C. Here, Ca/P in the number of atoms is set at about 1.3-1.9. After about 2hr of reaction, an reactant is filtered and dewatered to obtain hydroxy apatite [Ca10(PO4)6(OH)2]. The apatite thus obtained is less than 50m<2>/g and forms a hexagonal prism-shaped assembly. Thus, the reaction in the organic solvent enables the manufacture of a filling agent for chromatography of hydroxy apatite excellent in the separation performance in a constant character with a better reproducibility.
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