| 摘要 |
Compounds of the formula: <IMAGE> (I) and the pharmaceutically acceptable, non-toxic salts and esters (alkyl, 1-6C) thereof, wherein: X is O or S; R1 is selected from the group consisting of: (a) alkyl or cycloalkyl of 3-8 carbons, (b) <IMAGE> in which Z is O, S or -CH2, and Y is lower alkyl (1-4C), lower alkoxy (1-4C), halo, or -CF3, and (c) <IMAGE> in which Z and X are as herein defined; and R2 is hydrogen or methyl; exhibit prostaglandin-like activity and are, thus, useful as platelet aggregation inhibitors.
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