发明名称 |
(3'-ALKOXY-1'-ALKENYL)-CIS-BICYCLO(3.3.0)OCTENE DERIVATIVE |
摘要 |
<p>NEW MATERIAL:The compound of formula I (R<1> is 5-10C straight, branched or cyclic alkyl or alkenyl; R<2> and R<3> are H or OH-protecting group; R<4> is H or alkyl). EXAMPLE:3-( 4'-Carboxy-1'-butenyl-6( R )-[3'( S )-hydroxy-1'-trans-octenyl]-7(R)-hydroxy-(1S,5S)-cis-bicyclo[3.3.0]oct -2-ene. USE:Intermediate for the synthesis of 9(0)-methano-DELTA<6(9alpha)>-PGI1 useful as a remedy or preventive for circulatory diseases. PREPARATION:The compound of formula I can be produced by (1) introducing methylene group to the allylcyclopentanone derivative of formula II, (2) hydrating the resultant allylcyclopentylidene derivative of formula III, (3) oxidizing and dehydrating the obtained hydroxymethylcyclopentane derivative of formula VI, and (4) reacting the product with 3-carboxypropylphosphonium bromide.</p> |
申请公布号 |
JPS60139644(A) |
申请公布日期 |
1985.07.24 |
申请号 |
JP19830244695 |
申请日期 |
1983.12.27 |
申请人 |
SAGAMI CHUO KAGAKU KENKYUSHO |
发明人 |
SHIBAZAKI MASAKATSU;MASE TOSHIAKI;SODEOKA MIKIKO;OGAWA YUUJI |
分类号 |
C07D309/12;C07C51/00;C07C59/46;C07C59/62;C07C67/00;C07C69/732;C07C69/734;C07C69/78;C07F7/18 |
主分类号 |
C07D309/12 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|