发明名称 |
PEPTIDES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS OR DIAGNOSTIC AGENTS CONTAINING THEM |
摘要 |
New octapeptides of the general formula (I), X-Arg-Val-Tyr-Ile-His-Pro-Y-OA (I) wherein X stands for the acyl group of an N-methylamino acid or the acyl group of an aliphatic alpha -hydroxy- or alpha -aminooxycarboxylic acid, Y is the residue of an aliphatic amino acid, and A is a C1-5 alkyl group, are prepared so that the protecting groups of a protected octapeptide derivative of the general formula (II), B-X-Arg(C)-Val-Tyr(D)-Ile-His(E)-Pro-Y-OA (II) wherein B is a group removable by acidolysis or catalytic hydrogenation, C is a group for the temporary protection of the guanidino group on the Arg moiety, D is a group for the temporary protection of the aromatic hydroxy group on the Tyr moiety, E is a group for the temporary protection of the imidazole group on the His moiety, and A, X and Y are as defined above, are removed either stepwise or in a single step. If desired, a compound of the general formula (I) is converted into its acid addition salt or pharmaceutically acceptable complex. The new compounds according to the invention possess angiotensin-II antagonizing effects, and can be used in the therapy to diagnose or treat hypertensive states. |
申请公布号 |
DE3170906(D1) |
申请公布日期 |
1985.07.18 |
申请号 |
DE19813170906 |
申请日期 |
1981.01.19 |
申请人 |
RICHTER GEDEON VEGYESZETI GYAR R.T. |
发明人 |
NYEKI, OLGA, DIPL. CHEM.;KISFALUDY, LAJOS, DR. DIPL.-CHEM.-ING.;KARPATI, EGON, DR.;SZPORNY, LASZLO, DR. |
分类号 |
C07K7/06;A61K38/00;A61K38/08;A61K38/55;A61P9/12;C07K7/14;(IPC1-7):A61K37/02 |
主分类号 |
C07K7/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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