| 摘要 |
The invention comprises compounds of formula <FORM:1087694/C2/1> wherein R1 is a hydrogen atom or a C1- 4 alkyl group, R2 is a C1- 4 alkyl group, or R1 and R2 together with the linking carbon atom form a C5- 6 cycloalkylidene group, R3 and R4 each represent a hydrogen or halogen atom or a nitro, C1- 4 alkyl, C1- 4 alkoxy or C1- 4 alkanoyl group, Y is O, S, SO2 or NH, A is a C2- 8 alkylene, 2 - butyne - 1,4 diyl, C3- 12 alkanetviyl, C4- 6 alkanetetvayl, 1 - [4 - (C1- 2 alkoxy) carbonyl - 5 - (C1- 2 alkyl) - 2 - furyl] - butane 1,2,3,4 - tetvyle or 1,2,3,4,5,6 cyclohexanehexayl group, or a group -A1-Y1-A2, A1-O-A2-O-A3- or -A1-NR5-A2-, wherein A1, A2 and A3 are C2- 4 alkylene groups, Y1 is O, S, SO2 or 1,4 piperazinediyl and R5 is a C1- 4 alkyl, cyclohexyl or phenyl group, m is the valency of A and n is an integer from 1 to 6 not greater than m, and their preparation by esterification.ALSO:Tablets and powders having anti-hypercholesteremic activity are prepared from compounds of formula <FORM:1087694/A5-A6/1> wherein R1 is a hydrogen atom or a C1-4 alkyl group, R2 is a C1-4 alkyl group or R1 and R2 together with the linking carbon atom form a C5-6 cycloalkylidene group, R3 and R4 are each a hydrogen or halogen atom or a nitro, C1-4 alkyl, C1-4 alkoxy or C1-4 alkanoyl group Y is O, S, SO2 or NH, A is a C2-8 alkylene, 2-butyne-1, 4 diyl, C3-12 alkanetriyl, C4-6 alkanetetrayl, 1-[4-C1-2 alkoxy)-carbonyl-5(C1-2 alkyl -2-furyl-] butane-1,2,3,4-tetrayl or 1,2,3,4,5,6 cyclohexanehexayl group, or a group -A1-Y1 -A21-A1-O-A2-O-A3 or -A-NR5-A2 -, wherein A1, A2 and A3 are C2-4 alkylene groups, Y1 is O,S,SO2 or 1,4 piperazinediyl and R5 is a C1-4 alkyl, cyclohexyl or phenyl group, m is the valency of A and n is an integer from 1 to 6 not greater than n. Androsterone may be added. |
