摘要 |
<p>1-Alkyl 6-fluoro 7-(1-piperazinyl) 4-oxo 1,4-dihydro quinoline 3-carboxylic acids of formula (I) and their salts with physiologically acceptable acids are made by (a) reacting 3-chloro 4-fluoro (N-alkyl)aniline with ethoxy-methylene malonitrile to obtain 3-chloro 4-fluoro (N-alkyl)anilino methylene malonitrile of formula (II) (b) cyclising (II) under Friedel-Crafts conditions to obtain 1-alkyl 6-fluoro 7-chloro 4-imino 1,4-dihydroquinoline 3-carbonitrile of formula (III) and (c) reacting (III) with piperazine to obtain (I).</p> |