| 摘要 |
1. Indole derivatives of the general formula see diagramm : EP0144012,P18,F1 wherein Ind is an indol-3-yl radical which is substituted by a hydroxymethyl or COW group and which can additionally be monosubstituted or disubstituted by alkyl, O-alkyl, OH, F, Cl or Br, W is H, OH, Oalkyl, NH2 , NHalkyl or N(alkyl)2 , A is -(CH2 )n -, -CH2 -S-CH2 CH2 -, -CH2 -SO-CH2 CH2 -or-CH2 -SO2 -CH2 CH2 -, n is 2, 3, 4 or 5, the two radicals Y are each H or together are a C-C bond, one radical Z is Ar, the other radical Z is H and Ar is a phenyl group which is unsubstituted or is monosubstituted or disubstituted by O-alkyl and/or OH or is substituted by a methylenedioxy group, or Ar is a 2-thienyl or 3-thienyl group, in which formula each of the alkyl groups has 1 - 4 C atoms, wherein, however, when n is 2 or 3, the hydroxymethyl or COW group must be in the 4-, 5-, 6- or 7-position of the indol-3-yl radical, and also physiologically acceptable acid addition salts thereof. |
