| 摘要 |
<p>1,2,3,7,8,11-Hexahydro 3-oxo thieno (1,2-B) cyclo-hepta (5,6,7-de) isoquinoline of formula (I) is made by (a) the mixed (L) and (D) acids of formula (II) are reduced by sodium amalgam in absolute alcohol under reflux for 2-4 h. to give an acid of formula (III); (b) this is reacted with sodium azide in tetrahydrofurane at -10 to 15 deg.C to obtain an azide of formula (IV); (c) this is heated in inert solvent such as toluene, benzene or xylene, at 40-100 deg.C to obtain an isocyanate of formula (V); which (d) is cyclised in the same medium to give</p> |
