| 摘要 |
NEW MATERIAL:The compound of formula I [R1 and R2 are H, lower alkyl, etc.; X is group of formula II (R8 is H, lower alkyl, etc.; Z is single bond, -CH2-, -CH=CH-, etc.); R3 is H, Cl, methoxy, etc.; Y is -CH2CH2-, -CH=CH-, etc.; R4 is H, methoxy, benzoyl, etc.; R5-R7 are H, lower alkyl, amino, etc.]. EXAMPLE:4-{2-[4-(1-Phthalimidoethyl)phenyl]ethyl}benzamidine hydrochloride. USE:A cardiotonic agent having excellent activity to promote the myocardial contraction without increasing the pulse rate. It is useful as a remedy for cardiac insufficiency. PREPARATION:The compound of formula I can be produced by (1) reacting the xylene dihalide of formula III with the cyanophenol compound of formula IV, (2) reacting the reaction product with an amine compound, (3) adding an alcohol to the resultant compound of formula V in the presence of hydrogen chloride, and (4) condensing the reaction product with an amine compound. |
