| 摘要 |
PURPOSE:To lyophilize a small amt. of sample securely and to prevent deterioration of the sample by freezing liquid contg. the sample to form semispherical drops on a cooling plate and drying the frozen drops under reduced pressure. CONSTITUTION:Liquid contg. a sample comprising solution or suspension, etc. is dropped onto a plate cooled by liquid N2, etc. to such low temp. as capable of freezing the liquid instantly to semispherical frozen product, and the frozen product is further dried under reduced pressure at <=0 deg.C. Thus, a lyophilized product contg. desired agglutination activity units or desired units of weight, activity, or number of cell per dose, for red cell may be obtd. Further, since the product is lyophilized instantly due to its small surface area and dried without changing its shape, even easily deactivated samples such as virus can be lyophilized without deteriorating its activity with sufficient solubility preserved until it is renatured. Moreover, deterioration of the sample is held to the least degree since the sample does not directly contact a refrigerant at extremely low temp. |
