PROCESS FOR THE RESOLUTION OF PYRANO[3,4-B]INDOLE- 1-ACETIC ACIDS

摘要

Mixtures of racemic (?)pyrano¢3,4-b!indole-1-acetic acids are resolved with (-)-borneol to obtain the substantially pure (+) and (-)-enantiomers. The resolution involves the formation of a mixture of the diastereoisomeric pyrano¢3,4-b!indole-acetic acid, (-)-borneol esters, separation of the diastereoisomeric esters, and hydrolysis of the latter esters.