Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2-receptor antagonist activity

摘要

Histamine H2-receptor antagonists of the formula <IMAGE> I wherein A, m, Z, n and R1 are as defined herein, and their nontoxic pharmaceutically acceptable salts, hydrates and solvates are novel anti-ulcer agents which are prepared by ring closure of a substituted ethanediimidamide of the formula <IMAGE> II .