发明名称 |
2,6-Dioxopiperidine derivatives, their preparation and pharmaceutical compositions containing them. |
摘要 |
<p>In the treatment of oestrogen-dependent tumours, it is desirable to improve the therapy obtainable from the compound aminoglutethimide. It has now been found that 3-ethyl-3-(4-pyridyl)glutarimide and derivatives thereof of formula <CHEM> wherein R represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms offers advantages over aminoglutethimide. 3-Ethyl-3-(4-pyridyl)glutarimide can be prepared by various ring-closing reactions, especially by heating 4-(4-pyridyl)-hexano-1,4-dinitrile with a strong mineral acid.</p> |
申请公布号 |
EP0147121(A1) |
申请公布日期 |
1985.07.03 |
申请号 |
EP19840308570 |
申请日期 |
1984.12.10 |
申请人 |
NATIONAL RESEARCH DEVELOPMENT CORPORATION |
发明人 |
FOSTER, ALLAN BENTHAM;JARMAN, MICHAEL;TAYLOR, GRAHAME NIGEL;KWAN, CHUI-SHEUNG |
分类号 |
C12N9/99;A61K31/4427;A61K31/4465;A61K31/45;A61P25/08;A61P25/20;A61P35/00;C07D213/57;C07D401/00;C07D401/04;(IPC1-7):C07D401/04 |
主分类号 |
C12N9/99 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|