| 摘要 |
NEW MATERIAL:Fluoroblasticidin S shown by the formula I or its salts. USE:A fungicide of antibiotic for agriculture, an antibiotic showing improved effect especially on blast of rice plant. PREPARATION:A bacterium belonging to the genus Streptomyces, capable of producing blasticidin S is cultivated in the presence of fluorocytocine shown by the formula II in a culture solution containing a C source, N source, inorganic salt, a very small amount of organic omponents, etc. by shaking culture or by aerated spinner sulture at 20-40 deg.C, to give a compound shown by the formula I . Properties of monoacetate type fluoroblasticidin S. Melting pont: 215-220 deg.C. Molecular formula: C19H29N8O5F. Value of elemental analysis: theoretical value (wt%) C 48.71, H 6.24, N 23.92,) 17.08, measured value (wt%) C 48.52, H 6.30, N 23.43, O 17.21, etc.
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