发明名称 N-heterocyclic retinoic acid analogues
摘要 A compound of the formula: <IMAGE> where X is <IMAGE> +TR <IMAGE> and R is hydroxy, or an alkoxy with 0 or 1 hydroxy substituent, or aroxy with 0 or 1 hydroxy substituent, or alkoxy monosubstituted phenoxy, or NR1R2 where R1 is hydrogen, or an alkyl or aryl with 0 or 1 hydroxy substituent, and R2 is an alkyl or aryl with 0 or 1 hydroxy substituent. These compounds are useful as chemopreventive agents for inhibiting tumor promotion in ephithelial cells and for treating nonmalignant skin disorders.
申请公布号 US4526787(A) 申请公布日期 1985.07.02
申请号 US19830479182 申请日期 1983.03.28
申请人 SRI INTERNATIONAL 发明人 DAWSON, MARCIA I.;CHAN, REBECCA L. S.;HOBBS, PETER D.
分类号 C07D213/30;C07D213/48;C07D213/79;C07D213/80;C07D233/90;(IPC1-7):C07D213/79;C07D239/54;A61K31/505;A61K31/455 主分类号 C07D213/30
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