ANDROSTANE CARBOTHIOATES

摘要

Compds. of formula (I) are new wherein R1 represents a fluoro-, chloro- or bromo-methyl gp. or a 2'-fluoroethyl gp.; R2 represents a gp. COR6 where R6 is a C1-3 alkyl gp. or OR2 and R3 together form a 16 alpha, 17 alpha isopropylidenedioxy gp.; R3 represents a hydrogen atom, a methyl gp.(which may be in either the alpha- or beta- configuration) or a methylene gp.; R4 represents a hydrogen, chlorine or fluorine atom; R5 represents a hydrogen or fluorine atom and the dotted line represents a single or double bond. (I) are useful as topical antiflammatory agents.