| 摘要 |
PURPOSE:To obtain an antibiotic showing effects especially on agriculture, having a fluorine-containing aromatic nucleus, by cultivating a bacterium capable of producing vulgamycin in the presence of a compound having a fluorine-containing nucleus. CONSTITUTION:A bacterium belonging to the genus Streptomyces, capable of producing vulgamycin, is cultivated in the presence of a compound having a fluorine-containing aromatic uncleus shown by the formula I (R is alkyl, or other substituent groups; m is 0-4; n is 1-3, with the proviso that m+n <=5), having at least one fluorine atom linked to aromatic nucleus, under aerobic conditions at 10-50 deg.C, preferably at 20-45 deg.C, to give the desired substance shown by the formula II. A fluorine-containing benzoic acid such as o-fluorobenzoic acid, m- fluorobenzoic acid, etc. may be used preferably as the compound shown by the formula I .
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