| 摘要 |
<p>PURPOSE:To obtain the titled substance from inexpensive raw material in high yield easily, by carrying out simultaneously reduction of isopropenyl group of p-isopropenylacetophenone and reductive amination of carbonyl group in the presence of an Ni catalyst and ammonia. CONSTITUTION:p-Isopropenylacetophenone (A) is used as a raw material, treated in the presence of an Ni catalyst and 3-7mol ammonia based on 1mol compound A in an alcohol solvent at 70-130 deg.C at 20-100kg/cm<2>, so that reduction of isopropenyl group and reductive amination of carbonyl group are simultaneously carried out, to give the titled substance. Raney nickel catalyst, reductive nickel catalyst, or nickel catalyst obtained by decomposing thermally nickel formate, etc. are used as the catalyst. An amount of the catalyst used is preferably 2-20wt% calculated as Ni weight based on the compound A. USE:A purely synthetic basic optical resolution agent.</p> |
