| 摘要 |
1. Claims for the Contracting States BE, CH, DE, FR, GB, IT, LI, LU, NL, SE Piperidine derivatives of Formula (I) see diagramm : EP0077427,P8,F1 wherein R represents either a hydrogen atom, or a (C1-4 ) alkyl radical or a hydroxy (C1-4 )alkyl radical, or a (C1-4 )alkoxycarbonyl radical, or a benzyl radical optionally bearing a substituent selected from halogen atoms and (C1-4 )alkoxy radicals, or the phenethyl radical or the 3-phenyl-propyl radical, X represents one or more hydrogen or halogen atoms or (C1-4 )alkyl, (C1-4 )alkoxy, trifluoromethyl, methylenedioxy radicals, or X together with the phenyl ring forms a naphthyl radical, provided that R and X do not represent simultaneously hydrogen atoms, and their pharmaceutically acceptable acid addition salts. 1. Claim for the Contracting State : AT Process for the preparation of piperidine derivatives of Formula (I) see diagramm : EP0077427,P8,F2 wherein R represents either a hydrogen atom, or a (C1-4 ) alkyl radical or a hydroxy (C1-4 )alkyl radical, or a (C1-4 )alkoxycarbonyl radical, or a benzyl radical optionally bearing a substituent selected from halogen atoms and (C1-4 )alkoxy radicals, or the phenethyl radical or the 3-phenyl-propyl radical, X represents one or more hydrogen or halogen atoms or (C1-4 )alkyl, (C1-4 )alkoxy, trifluoromethyl, methylenedioxy radicals, or X together with the phenyl ring forms a naphthyl radical, provided that R and X do not represent simultaneously hydrogen atoms, and their pharmaceutically acceptable acid addition salts, process characterized in that a compound (II) see diagramm : EP0077427,P8,F4 wherein R' represents a protecting radical for the nitrogen, such as a 4-nitro-benzoyl radical, optionally substituted benzoyl radical, optionally substituted benzyl radical or alkyl radical, is reacted with a compound (III) see diagramm : EP0077427,P8,F6 wherein Y represents a reactive radical such as bromine or chlorine ; then the protecting radical R' is either eliminated when it does not correspond to a R radical, or the protecting, optionally substituted, benzoyl group is reduced, either a compound (I) see diagramm : EP0077427,P8,F8 is reacted with a compound RZ, wherein Z is a reactive group, so as to graft the R radical. |
