| 摘要 |
<p>Novel adenosine derivatives of the general formula <FORM:1101108/C2/1> wherein R is a saturated or unsaturated, straight or branched-chain aliphatic hydrocarbon radical and X is a halogen atom, an azido group or an alkylmercapto radical, are prepared either by reaction of a compound of the general formula <FORM:1101108/C2/2> wherein Z is a hydrogen atom or a formyl radical, or the 21,31-isopropylidene derivative thereof, with an N-alkylation or N-alkenylation agent of the formula RI, optionally in the presence of barium hydroxide, and thereafter, if necessary, removal of the protective groups by acid hydrolysis, or by reaction of a compound of the general formula <FORM:1101108/C2/3> wherein Y is the residue of a sulphonic acid, preferably a tosyl radical, with an alkali metal compound of the formula MeX, in which Me is an alkali metal atom, followed by removal of the protective groups by acid hydrolysis. 21,31 - O - Isopropylidene - N(6) - allyl - 51 - O - tosyl-adenosine is prepared by reaction of p-toluene-sulphonyl chloride with 21,31-O-isopropylidene - N(6) - allyl - adenosine, formed by reaction of 21,31-O-isopropylidene-adenosine in dimethyl formamide with allyl iodide.</p> |
