发明名称 |
2-[4-(Diphenylmethyl)-1-piperazinyl]-acetic acids and their amides |
摘要 |
New 2-[4-(diphenylmethyl)-1-piperazinyl]-acetic acids, their amides and their salts, processes for the preparation thereof and therapeutic compositions. These compounds have the formula <IMAGE> wherein Y=-OH or -NH2; X and X'=H, halogen, alkoxy or trifluoromethyl; m=1 or 2 and n=1 or 2. The amides of the 2-[4-(diphenylmethyl)-1-piperazinyl]-acetic acids are prepared either by reacting a 1-(diphenylmethyl)-piperazine with an omegahaloacetamide, or by reacting an alkali metal salt of an omega-[4-(diphenylmethyl)-1-piperazinyl]-alkanol with a 2-haloacetamide, or yet by reacting ammonia with a halide or alkyl ester of a 2-[4-(diphenylmethyl)-1-piperazinyl]-acetic acid, whereas the 2-[4-(diphenylmethyl)-1-piperazinyl]-acetic acids are prepared by hydrolyzing the corresponding amide or lower alkyl ester. These compounds have in particular an antiallergic, spasmolytic and antihistaminic activity.
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申请公布号 |
US4525358(A) |
申请公布日期 |
1985.06.25 |
申请号 |
US19830496489 |
申请日期 |
1983.05.17 |
申请人 |
UCB PHARMACEUTICALS, INC. |
发明人 |
BALTES, EUGENE;DE LANNOY, JEAN;RODRIGUEZ, LUDOVIC |
分类号 |
C07D295/08;A61K31/495;A61P37/08;C07D295/088;(IPC1-7):A61K31/50;C07D295/14 |
主分类号 |
C07D295/08 |
代理机构 |
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主权项 |
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地址 |
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