| 摘要 |
PURPOSE:To obtain the titled compound useful as an intermediate for drugs, and agricultural chemicals by one stage in high yield, by reacting an industrially easily obtainable p-(substituted methyl)phenyl ketone with an orthoformic acic alkyl ester and a trivalent iodine compound in the presence of an acid. CONSTITUTION:A p-(substituted methyl)phenylketone [e.g., 4-(chloromethyl)propiophenone, etc.] shown by the formula I (X is halogen, or alkoxy; R<1> is H, or methyl) is reacted with an orthoformic acid alkyl ester (e.g., orthoformic acid ethyl ester, etc.) shown by the formula II (R<2> is alkyl) and a trivalent iodine compound (e.g., iodobenzene diacetate, etc.) shown by the formula III (Y is halogen, or acyloxy) in the presence of an acid such as sulfuric acid, etc. to give a compound {e.g., 2-[4-(chloromethyl)phenyl]propionic acid ethyl ester, etc.} shown by the formula IV. The compound shown by the formula I is obtained easily from 4-mthylpropiophenone, etc. EFFECT:Having no problem of selectivity for o, m, and p positions.
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