| 摘要 |
PURPOSE:To produce the titled compound useful as a raw material for the esterification of cephalosporin, penicillin, etc., in high yield and purity, by reacting a carboxylic acid iodide with an aldehyde. CONSTITUTION:The objective 1-iodoalkyl acylate can be produced by reacting a carboxylic acid iodide with an aldehyde. The reaction is carried out either by (1) reacting a carboxylic acid chloride with a hydroiodic acid salt (e.g. NaI) and then reacting the resultant carboxylic acid iodide with an aldehyde, or (2) reacting the carboxylic acid chloride with a hydroiodic acid salt and an aldehyde at the same time. The amount of the carboxylic acid chloride is about 1-3mol per 1mol of the aldehyde, and that of the hydroiodic acid salt is about 1-3 equivalent based on the carboxylic acid chloride. The reaction is carried out usually in an inert solvent. The side reactions are suppressed, and the objective compound can be produced in high yield and purity.
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