发明名称 CHEMICAL PROCESS FOR THE SYNTHESIS OF MACROLIDE ANTIBIOTICS
摘要 Fluorinated derivatives of erythromycins A, B, C and D, having antibiotic activity, are prepared, starting from 8,9-anhydroerythromycin 6,9-hemiacetals or their N-oxides, through the reaction with a compound capable of generating electrophilic reactive fluorine, the resulting reaction product undergoing thereafter a reduction, possibly together with a methylation, to the corresponding (8S)-8-fluoroerythomycins.
申请公布号 PH18391(A) 申请公布日期 1985.06.21
申请号 PH20030000282 申请日期 1982.11.26
申请人 PIERREL SPA. 发明人 LUCIANO TOSCANO
分类号 C07H17/00;A61K31/70;A61K31/7042;A61K31/7048;A61P31/04;C07H17/08 主分类号 C07H17/00
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