发明名称 |
MANUFACTURE OF MANNICH BASE |
摘要 |
A process for preparing 2-(2-(5-dimethylaminomethylfuran-2-ylmethylthio)ethylamino)-5-(2-metho xypyrid-4- ylmethyl)pyrimidin-4-one which comprises reacting 2-(2-(furan-2-ylmethylthio)ethylamino)-5-(2-methoxypyrid-4-ylmethyl)py rimidin-4- one with a organic solution of bis(dimethylamino)methane at a pH of about 1.3 to about 2.5. The product is an H2-antagonist and also is of value in forming 2-(2-(5-dimethylaminomethylfuran-2-yl-methylthio)ethylamino)-5-(2-hydr oxypyrid-4 -ylmethyl)pyrimidin-4-one by deprotecting. |
申请公布号 |
JPS60109588(A) |
申请公布日期 |
1985.06.15 |
申请号 |
JP19840220322 |
申请日期 |
1984.10.18 |
申请人 |
SMITH KLINE & FRENCH LAB LTD |
发明人 |
BURAIAN MIKAERU ADOGAA;NOOMAN JIYON RUISU |
分类号 |
C07D405/14 |
主分类号 |
C07D405/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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